azathioprine

/az'euh thuy"euh preen'/, n. Pharm.
a cytotoxic purine analog, C9H7N7O2S, used as an immunosuppressive in organ transplantations and in rheumatoid arthritis and connective tissue disorders.
[1960-65; coinage appar. based on imidazol, THIO-, and PURINE, parts of the chemical name]

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drug
      immunosuppressive drug that is used to treat rheumatoid arthritis and to suppress the body's rejection of transplanted organs. By inhibiting several enzymatic pathways required for the synthesis of deoxyribonucleic acid (DNA) (DNA), azathioprine decreases the number of lymphocytes (lymphocyte) (a type of white blood cell) that can migrate to inflammatory sites. leukopenia (an abnormally low number of white blood cells in the circulation) is the major undesirable side effect of the drug, although anemia and hemorrhage may also occur. When used with allopurinol, the pharmacological effect of azathioprine is increased.

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Universalium. 2010.

Look at other dictionaries:

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  • azathioprine — n. an immunosuppressant drug, used mainly to aid the survival of organ or tissue transplants. It may also be used in the treatment of rheumatoid arthritis (see disease modifying antirheumatic drug) and myasthenia gravis. Azathioprine may damage… …   The new mediacal dictionary

  • azathioprine — noun an immunosuppressive drug (trade name Imuran) used to prevent rejection of a transplanted organ • Syn: ↑Imuran • Usage Domain: ↑trademark (for: ↑Imuran) • Hypernyms: ↑medicine, ↑ …   Useful english dictionary

  • azathioprine — noun Etymology: aza + thi + purine Date: 1962 a purine antimetabolite C9H7N7O2S used especially as an immunosuppressant …   New Collegiate Dictionary

  • azathioprine — noun A particular immunosuppressant …   Wiktionary

  • azathioprine — aza·thi·o·prine …   English syllables

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