Mello, Craig C.
▪ American geneticistborn Oct. 18, 1960, New Haven, Conn., U.S.American scientist, who was a corecipient, with Andrew Z. Fire (Fire, Andrew Z.), of the Nobel Prize for Physiology or Medicine in 2006 for discovering RNA interference (RNAi), a mechanism that regulates gene activity.Mello grew up in northern Virginia, and, as a young boy, he developed an intense curiosity in the living world. His curiosity was largely influenced by his father, James Mello, a paleontologist who had served as the associate director of the National Museum of Natural History at the Smithsonian Institution in Washington, D.C. Mello was intrigued by fundamental concepts such as evolution. He felt that these concepts encouraged humans to ask questions about the world around them, a belief that led to his rejection of religion at a young age. Mello attended Brown University in Providence, Rhode Island, studying biochemistry and molecular biology and receiving a B.S. degree in 1982. He began his graduate studies in biology at the University of Colorado (Colorado, University of) in Boulder, where he worked in the laboratory of American molecular biologist David Hirsh, who was investigating the nematode Caenorhabditis elegans. While conducting research in Hirsh's lab, Mello was introduced to American molecular biologist Dan Stinchcomb. When Stinchcomb decided to move to Harvard University in Cambridge, Mass., to start his own research laboratory, Mello decided to follow him. At Harvard Mello became deeply involved in research on C. elegans, and his studies led him to American scientist Andrew Z. Fire, who was working at the Carnegie Institution for Science in Baltimore, Md. Both Mello and Fire were working to find a way to insert DNA into C. elegans, a process known as DNA transformation. After exchanging ideas and elaborating on one another's experiments, they successfully developed a procedure for DNA transformation in nematodes. In 1990, following the completion of his thesis, C. elegans DNA Transformation, Mello graduated from Harvard with a Ph.D. in biology.Mello worked at the Fred Hutchinson Cancer Research Center in Seattle, Wash., from 1990 to 1994. He continued studying C. elegans, though his focus had shifted to identifying genes (gene) involved in regulating nematode development. In 1994 Mello joined the faculty at the University of Massachusetts (Massachusetts, University of) Medical School. He became interested in an RNA injection technique used to silence genes. Silencing genes in C. elegans enabled Mello to identify the functions of the genes he had discovered while working in Seattle. He soon found that some nematode embryos (embryo) that had been injected with RNA to silence certain genes were able to transmit the silencing effect to their offspring. Mello and Fire worked in collaboration to uncover the cellular mechanism driving this active silencing phenomenon and discovered that the genes were being silenced by double-stranded RNA. Known as RNAi, this mechanism regulates gene activity and helps defend against viral infection. In 1998 they published their findings, for which they later received the Nobel Prize. RNAi has proved a valuable research tool, enabling scientists to block genes in order to uncover the basic functions and roles of genes in disease. RNAi can also be used to develop new treatments for a number of diseases, including AIDS, cancer, and hepatitis. Following the RNAi publication, Mello focused his research on applying the silencing technique to the study of embryonic cell differentiation in C. elegans. In 2000 Mello was awarded the title of Howard Hughes Medical Investigator because of his significant contributions to science.
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Craig Mello — Craig Cameron Mello Born October 18, 1960 (1960 10 18) (age 51) New Haven, Connecticut Residence Un … Wikipedia
Craig C. Mello — Craig Mello, 2006 Craig Cameron Mello (* 18. Oktober 1960) ist ein amerikanischer Biochemiker und Nobelpreisträger für Medizin. Inhaltsverzeichnis 1 Leben 2 Auszeichnungen … Deutsch Wikipedia
Craig Cameron Mello — Craig Mello, 2006 Craig Cameron Mello (* 18. Oktober 1960) ist ein amerikanischer Biochemiker und Nobelpreisträger für Medizin. Inhaltsverzeichnis 1 Leben 2 Auszeichnungen … Deutsch Wikipedia
Craig Mello — Craig Cameron Mello (* 18. Oktober 1960) ist ein US amerikanischer Biochemiker und Nobelpreisträger für Medizin. Inhaltsverzeichnis 1 Leben 2 Auszeichnungen 3 Quellen 4 Weblinks … Deutsch Wikipedia
Craig C. Mello — Saltar a navegación, búsqueda Craig C. Mello (nacido en 1960) es co ganador del Premio Nobel de Fisiología o Medicina 2006 junto con Andrew Fire por el descubrimiento de la ribointerferencia o interferencia por ARN (RNAi). Craig Mello recibió su… … Wikipedia Español
Craig Mello — Craig C. Mello Pour les articles homonymes, voir Mello (homonymie). Craig Cameron Mello, né le 18 octobre 1960 à New Haven dans le Connecticut, est un scientifique américain travaillant à la University of Massachusetts Medical School, qui a… … Wikipédia en Français
Mello (disambiguation) — Mello can refer to: Places Mello, an Italian commune Mello, Oise, French commune Mello, California, American community Mello, Ethiopia, small town People Anna Vania Mello, Italian volleyball player Big Mello, American rapper Branco Mello,… … Wikipedia
Mello — steht für: Mello (Lombardei), Gemeinde in Italien Mello (Oise), Gemeinde in Frankreich Personen: Anthony de Mello (1931–1987), Jesuitenpriester und spiritueller Lehrer Breno Mello (1931–2008), brasilianischer Schauspieler und Fußballspieler… … Deutsch Wikipedia
Craig C. Mello — Pour les articles homonymes, voir Mello (homonymie). Craig Cameron Mello, né le 18 octobre 1960 à New Haven dans le Connecticut, est un scientifique américain travaillant à la University of Massachusetts Medical School, qui a obtenu avec Andrew Z … Wikipédia en Français
Mello (homonymie) — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Mello est une commune française, située dans le département de l Oise. Mello est une commune italienne de la province de Sondrio. Craig C. Mello est un… … Wikipédia en Français