Cori, Carl; and Cori, Gerty

▪ American biochemists
in full, respectivelyCarl Ferdinand Cori  and  Gerty Theresa Cori,  née  Radnitz  
Respectively,
 
born Dec. 5, 1896, Prague, Czech.
died Oct. 20, 1984, Cambridge, Mass., U.S.
born Aug. 15, 1896, Prague, Czech.
died Oct. 26, 1957, St. Louis, Mo., U.S.

      American biochemists, husband-and-wife team whose discovery of a phosphate-containing form of the simple sugar glucose, and its universal importance to carbohydrate metabolism, led to an understanding of hormonal influence on the interconversion of sugars and starches in the animal organism. Their discoveries earned them (with Bernardo Houssay (Houssay, Bernardo Alberto)) the Nobel Prize for Medicine or Physiology in 1947.

      They met while students at the German University of Prague and were married in 1920, receiving their medical degrees the same year. Immigrating to the United States in 1922, they joined the staff of the Institute for the Study of Malignant Disease, Buffalo, N.Y. (1922–31). As faculty members of the Washington University medical school, St. Louis (from 1931), they discovered (1936) the activated intermediate, glucose 1-phosphate (phosphate bound to a specific carbon atom on the glucose molecule), known as the “Cori ester.” They demonstrated that it represents the first step in the conversion into glucose of the animal storage carbohydrate glycogen, large quantities of which are found in the liver, and—because the reaction is reversible—in some cases the last step in the conversion of blood glucose to glycogen.

      Six years later they isolated and purified the enzyme (glycogen phosphorylase) responsible for catalyzing the glycogen-Cori ester reaction, and with it they achieved the test-tube synthesis of glycogen in 1943. Proof of the interconversion allowed them to formulate the “Cori cycle,” postulating that liver glycogen is converted to blood glucose that is reconverted to glycogen in muscle, where its breakdown to lactic acid provides the energy utilized in muscle contraction. The lactic acid is used to re-form glycogen in the liver. Studying the way in which hormones affect carbohydrate metabolism in animals, the Coris showed that epinephrine (epinephrine and norepinephrine) induces the formation of a type of phosphorylase enzyme favouring conversion of glycogen to activated glucose and that insulin causes the removal of sugar from the blood by promoting the addition of phosphate to glucose. The Coris trained a large number of graduate students and postdoctoral fellows from all over the world.

      After his wife's death Carl Cori devoted his efforts to research concerning the physico-chemical action of enzymes involved in the breakdown of glycogen to lactic acid.

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Universalium. 2010.

Look at other dictionaries:

  • CORI, GERTY THERESA — (née Radnitz; 1896–1957), Nobel laureate in medicine and physiology. Cori was born in Prague, where she graduated in medicine from the German University in 1920. That year she married her fellow student and lifelong scientific collaborator, Carl… …   Encyclopedia of Judaism

  • Cori , Gerty Theresa Radnitz — (1896–1957) Czech–American biochemist Gerty Radnitz was born in the Czech capital of Prague and graduated from the Medical School there in 1920, the year in which she married her lifelong collaborator Carl Cori. She moved with him to America,… …   Scientists

  • Cori,Gerty Theresa Radnitz — Co·ri (kôrʹē, kōrʹē), Gerty Theresa Radnitz. 1896 1957. Czech born American biochemist. She shared a 1947 Nobel Prize with her husband, Carl Ferdinand Cori (1896 1984), and Bernardo A. Houssay for discovering the intermediate steps in glycogen… …   Universalium

  • Gerty Cori — (1947) Gerty Theresa Cori (geborene Radnitz) (* 15. August 1896 in Prag; † 26. Oktober 1957 in St. Louis, Missouri) war eine böhmisch amerikanische Biochemikerin und Nobelpreisträgerin. Leben …   Deutsch Wikipedia

  • Gerty Cori — Gerty Theresa Cori Gerty Cori. Gerty Theresa Cori (Prague 15 août 1896 – 26 octobre 1957), née Radnitz, est une biochimiste américaine d origine austro hongroise …   Wikipédia en Français

  • Gerty T. Cori — Gerty Theresa Cori Gerty Cori. Gerty Theresa Cori (Prague 15 août 1896 – 26 octobre 1957), née Radnitz, est une biochimiste américaine d origine austro hongroise …   Wikipédia en Français

  • Gerty Cori — Gerty Cori …   Wikipedia Español

  • Carl Ferdinand Cori — Infobox Scientist name = Carl Ferdinand Cori box width = image size = 150px caption = Carl Ferdinand Cori birth date = December 5, 1896 birth place = Prague death date = October 20, 1984 death place = residence = citizenship = nationality =… …   Wikipedia

  • Gerty Cori — Dr. Gerty Theresa Cori, née Radnitz, (August 15, 1896 ndash; October 26, 1957) was an American biochemist born in Prague (Austrian Empire, now Czech Republic) who, together with her husband Carl Ferdinand Cori and Argentine physiologist Bernardo… …   Wikipedia

  • Gerty Theresa Cori — Pour les articles homonymes, voir Cori. Gerty Cori. Gerty Theresa Cori (15 août 1896 à Prague – 26 …   Wikipédia en Français

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