- Blood disorder (see hemoglobinopathy) seen mainly in persons of Sub-Saharan African ancestry and their descendants and in those from the Middle East, the Mediterranean area, and India.About 1 in 400 blacks worldwide has the disease, caused by inheriting two copies of a recessive gene that makes those with one copy (about 1 in 12 blacks worldwide) resistant to malaria. The gene specifies a variant hemoglobin (hemoglobin S or Hb S) that distorts red blood cells (erythrocytes) into a rigid sickle shape. The cells become clogged in capillaries, damaging or destroying various tissues. Symptoms include chronic anemia, shortness of breath, fever, and episodic "crises" (severe pain in the abdomen, bones, or muscles). Hydroxyurea treatment triggers production of fetal hemoglobin (Hb F), which does not sickle, greatly lessening severity of crises and increasing life expectancy, previously about 45 years.
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sickle-cell anemia — n a chronic anemia that occurs in individuals (as those of African or Mediterranean descent) who are homozygous for the gene controlling hemoglobin S and that is characterized by destruction of red blood cells and by episodic blocking of blood… … Medical dictionary
sickle-cell anemia — sickle cell anemia. См. серповидноклеточная анемия. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
sickle cell anemia — Pathol. a chronic hereditary blood disease, occurring primarily among Africans or persons of African descent, in which abnormal hemoglobin causes red blood cells to become sickle shaped and nonfunctional, characterized by enlarged spleen, chronic … Universalium
Sickle cell anemia — A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body. Sickle cell anemia affects… … Medical dictionary
sickle cell anemia — An inherited disease in which the red blood cells have an abnormal crescent shape, block small blood vessels, and do not last as long as normal red blood cells. Sickle cell anemia is caused by a mutation (change) in one of the genes for… … English dictionary of cancer terms
sickle cell anemia — sickle cell a nemia noun uncount a blood disease that mainly affects black people … Usage of the words and phrases in modern English
sickle-cell anemia — noun a congenital form of anemia occurring mostly in blacks; characterized by abnormal blood cells having a crescent shape • Syn: ↑sickle cell anaemia, ↑sickle cell disease, ↑crescent cell anemia, ↑crescent cell anaemia, ↑drepanocytic anemia,… … Useful english dictionary
sickle-cell anemia — noun Date: 1922 a chronic inherited anemia that occurs primarily in individuals of African, Mediterranean, or southwest Asian ancestry who are homozygous for the gene controlling hemoglobin S and that is characterized especially by episodic… … New Collegiate Dictionary
sickle-cell anemia — noun A disease characterized by sickle shaped red blood cells. Syn: sickle cell disease … Wiktionary
sickle cell anemia — Synonyms and related words: Christmas disease, Hand Schuller Christian disease, Hartnup disease, Letterer Siwe syndrome, Werdnig Hoffmann disease, achromatic vision, acute leukemia, albinism, anemia, angiohemophilia, aplastic anemia, chronic… … Moby Thesaurus
sickle cell anemia — sick′le cell ane′mia n. pat a chronic hereditary blood disease, primarily affecting indigenous Africans and their descendants, in which an accumulation of oxygen deficient sickle cells results in anemia, blood clotting, and joint pain Also called … From formal English to slang