Fleming, Sir Alexander
- born Aug. 6, 1881, Lochfield, Ayr, Scot.died March 11, 1955, London, Eng.Scottish bacteriologist.While serving in the Royal Army Medical Corps in World War I, he conducted research on antibacterial substances that would be nontoxic to humans. In 1928 he inadvertently discovered penicillin when he noticed that a mold contaminating a bacterial culture was inhibiting the bacteria's growth. He shared a 1945 Nobel Prize with Ernst Boris Chain and Howard Walter Florey, who both carried Fleming's basic discovery further in isolating, purifying, testing, and producing penicillin in quantity.
* * *▪ Scottish bacteriologistborn August 6, 1881, Lochfield, Ayr, Scotlanddied March 11, 1955, London, EnglandScottish bacteriologist whose discovery of penicillin (1928) prepared the way for the highly effective practice of antibiotic therapy for infectious diseases. Fleming shared the Nobel Prize for Physiology or Medicine in 1945 with Ernst Boris Chain (Chain, Sir Ernst Boris) and Howard Walter Florey (Florey, Howard Walter Florey, Baron), who both (from 1939) carried Fleming's basic discovery further in the isolation, purification, testing, and quantity production of penicillin.After taking his degree at St. Mary's Hospital Medical School, London University (1906), Fleming conducted experiments to discover antibacterial substances that would be nontoxic to human tissues. He continued his research while serving with distinction in the Royal Army Medical Corps in World War I. In 1918 he returned to research and teaching at St. Mary's, where he was professor of bacteriology from 1928 to 1948, when he became professor emeritus.In 1921 Fleming identified and isolated lysozyme, an enzyme found in certain animal tissues and secretions, such as tears and saliva, that exhibits antibiotic activity. While working with staphylococcus bacteria in 1928, Fleming noticed a bacteria-free circle around a mold growth (spores of Penicillium notatum) that was contaminating a culture of the staphylococci. Investigating, he found a substance in the mold that prevented growth of the bacteria even when it was diluted 800 times. He called it penicillin. Fleming found that penicillin is nontoxic but that it inhibits the growth of many types of disease-causing bacteria. He was aware of the significance of his discovery, but he lacked the necessary chemical means to isolate and identify the active compound involved. He obtained enough penicillin to use on humans topically for skin and eye infections. It was not until 11 years later in 1939, during World War II, that the pressing need for new antibacterial drugs provided the impetus for Chain and Florey's active development of penicillin.Fleming was elected a fellow of the Royal Society in 1943 and knighted in 1944.Additional ReadingTwo biographies are Laurence James Ludovici, Fleming, Discoverer of Penicillin (1952); and Gwyn Macfarlane, Alexander Fleming, the Man and the Myth (1984).
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Fleming,Sir Alexander — Fleming, Sir Alexander. 1881 1955. British bacteriologist who discovered penicillin in 1928, for which he shared a Nobel Prize in 1945. * * * … Universalium
Fleming , Sir Alexander — (1881–1955) British bacteriologist Fleming was born at Lochfield in Scotland. After his early education at Kilmarnock Academy and the London Polytechnic Institute, he began his career at the age of 16 as a shipping clerk in a London office. With… … Scientists
Fleming, Sir Alexander — (6 ago. 1881 Lochfield, Ayr, Escocia–11 mar. 1955, Londres, Inglaterra). Bacteriólogo escocés. Mientras servía en el Cuerpo Médico del Ejército Real durante la primera guerra mundial, realizó investigaciones sobre sustancias antibacterianas que… … Enciclopedia Universal
Fleming, Sir Alexander — (1881–1955) British bacteriologist, discoverer of penicillin; shared Nobel Prize for Physiology or Medicine in 1945 … Bryson’s dictionary for writers and editors
Sir Alexander Fleming — Alexander Fleming auf einer Briefmarke Sir Alexander Fleming (* 6. August 1881 in Lochfield bei Darvel, East Ayrshire; † 11. März 1955 in London) war ein schottischer Bakteriologe und Nobelpreisträger und … Deutsch Wikipedia
Sir Alexander Fleming College — (commonly known as Fleming College or simply Fleming) is a British school in Trujillo, northern Perú. Fleming College represents Cambridge University and has an agreement with Markham College in Lima, Perú. Many of the Fleming staff are from… … Wikipedia
Sir Alexander Fleming — noun Scottish bacteriologist who discovered penicillin (1881 1955) • Syn: ↑Fleming, ↑Alexander Fleming • Instance Hypernyms: ↑bacteriologist … Useful english dictionary
Fleming — Sir Alexander … Scientists
Alexander — Alexander, Christopher Alexander, islas de Alexander, sir Harold * * * (as used in expressions) William Alexander Abbott Agassiz, Alexander (Emmanuel Rodolphe) Alexander, archipiélago Alexander, Harold (Rupert Leofric George) Alexander, 1 conde… … Enciclopedia Universal
Fleming — Fleming, Alexander Fleming, Ian Fleming, Victor * * * (as used in expressions) Fleming, Ian (Lancaster) Fleming, Peggy (Gale) Fleming, Sir Alexander … Enciclopedia Universal