tolbutamide

/tol byooh"teuh muyd'/, n. Pharm.
a white crystalline substance, C12H18N2O3S, used to augment insulin secretion in the treatment of diabetes mellitus.
[1955-60; TOL(U) + BUT(YL) + AMIDE]

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drug
      drug used in the treatment of type II (non-insulin-dependent) diabetes (diabetes mellitus). Tolbutamide stimulates the release of insulin from the pancreas, thereby reducing the concentration of glucose in the blood.

      Tolbutamide is one of a class of compounds called sulfonylureas and was the first agent of this type to be widely administered. Though discovered in the 1940s, sulfonylureas were not used until the mid-1950s to control type II diabetes. Tolbutamide is used to treat patients with mild to moderate diabetes that cannot be controlled by diet alone. It is quickly metabolized and is usually administered in divided doses. The drug has been associated with an increased mortality due to cardiovascular disease.

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Universalium. 2010.

Look at other dictionaries:

  • Tolbutamide — Systematic (IUPAC) name N [(butylamino)carbonyl] 4 methylbenzenesulfonamide Clinical data AHFS/Drugs.com …   Wikipedia

  • tolbutamide — [ tɔlbytamid ] n. m. • v. 1960; de tol(yle), but(yle) et amide ♦ Méd. Sulfamide administré par voie buccale dans le traitement du diabète. ● tolbutamide ou tolglybutamide nom masculin Dénomination courante d un sulfamide hypoglycémiant …   Encyclopédie Universelle

  • tolbutamide — ☆ tolbutamide [täl byo͞ot′ə mīd΄ ] n. [ TOL(U) + BUT(YRIC) + AMIDE] an oral drug, C12H18N2O3S, that stimulates the pancreas to secrete more insulin, used to treat diabetes …   English World dictionary

  • tolbutamide — noun Etymology: tol + butyric + amide Date: 1956 a sulfonylurea C12H18N2O3S used in the treatment of diabetes …   New Collegiate Dictionary

  • tolbutamide — A sulphonylurea that will bind to SUR and enhance insulin release from pancreatic B cells. Used in Type II diabetes (as are a number of similar drugs) …   Dictionary of molecular biology

  • tolbutamide — noun A drug that blocks potassium channels, used in the treatment of diabetes …   Wiktionary

  • tolbutamide — An orally active hypoglycemic agent used in the management of adult onset diabetes mellitus; it appears to stimulate the synthesis and release of endogenous insulin from functional islets; available as t. sodium for injection. * * *… …   Medical dictionary

  • tolbutamide — tol·bu·ta·mide …   English syllables

  • tolbutamide — n. a drug taken by mouth in the treatment of type 2 diabetes mellitus. It acts directly on the pancreas to stimulate insulin production and is particularly effective in elderly patients with mild diabetes (see sulphonylurea). Side effects may… …   The new mediacal dictionary

  • tolbutamide — noun sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult onset diabetes mellitus • Syn: ↑Orinase • Usage Domain: ↑trade name (for: ↑Orinase) • Hypernyms: ↑sulfonylure …   Useful english dictionary

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