- /theuh lid"euh muyd'/, n.a crystalline, slightly water-soluble solid, C13H10N2O4, formerly used as a sedative: if taken during pregnancy, it may cause severe abnormalities in the limbs of the fetus.[1955-60; (ph)thal(im)ido(glutari)mide = phthalimide (PHTHAL(IC) + IMIDE) + -O- + glutarimide (GLUT(EN) + (TART)AR(IC) + IMIDE)]
* * *Drug formerly used as a sedative and to prevent morning sickness during pregnancy.Synthesized in 1954, it was introduced in almost 50 countries, including West Germany and Britain, where it became popular because it was effective and huge overdoses were not fatal. In 1961 it was found to cause congenital disorders; when it is taken in early pregnancy, some 20% of fetuses have phocomelia (defective development of the limbs) and other deformities; 5,000–10,000 such babies were born. It was never distributed for clinical use in the U.S. (see Helen Brooke Taussig). Thalidomide appears effective against inflammatory and autoimmune disorders, including certain late-stage AIDS symptoms, and is licensed for use in such treatments in some countries.
* * *compound in medicine initially used as a sedative and an antiemetic until the discovery that it caused severe fetal malformations. Thalidomide was developed in West Germany in the mid-1950s and was found to induce drowsiness and sleep. The drug appeared to be unusually safe, with few side effects and little or no toxicity even at high doses. Further testing revealed that thalidomide was particularly well-suited to alleviating nausea and other symptoms associated with morning sickness in pregnant women. The drug's potentially harmful effects on the fetuses of certain mammals was not recognized during testing.Thalidomide went on the market as a treatment for morning sickness in more than 40 countries beginning in 1958. It was soon found to produce severe malformations in infants born of mothers who had taken the drug during early pregnancy. These included phocomelia (“seal limbs,” in which the long bones in the arms and legs fail to develop) and other deformities such as absence or malformation of the external ear, fusion defects of the eye, and absence of the normal openings of the gastrointestinal tract. Fetuses are vulnerable to the drug's effects only during the period from 27 to 40 days after conception, but the drug nonetheless caused deformities in an estimated 5,000 to 10,000 infants. Once these effects became known, thalidomide was taken off the market in 1961–62. In the United States, the Food and Drug Administration (FDA) had been slow to approve thalidomide, so it was never distributed for clinical use there.Teratogens (agents that cause birth defects) are still not fully understood. In the late 1950s physicians and pharmacologists little suspected that drugs that were nontoxic to an adult could cause deformations in a fetus. The issue was also complicated by the fact that thalidomide is harmful only during specific times in human fetal development.Though it achieved worldwide notoriety as a cause of birth defects and was withdrawn from use as a sedative, thalidomide eventually proved to have therapeutic uses. In the mid-1960s clinicians discovered that it can effectively treat the painful skin nodules and nerve impairment caused by erythema nodosum leprosum (erythema) (ENL), a complication of leprosy. Thalidomide achieves this therapeutic effect by limiting the immune system's powerful—and harmful—inflammatory response to leprosy bacilli within the body. Further testing revealed that thalidomide also has a significant anti-inflammatory effect in the treatment of rheumatoid arthritis and other autoimmune diseases. Thalidomide derives this effect from its ability to inhibit the body's production of tumour necrosis factor (TNF), a protein that is a powerful stimulator of inflammation within the body.In the 1990s thalidomide was found to be effective in treating cachexia, the severe weight loss that occurs in patients with diseases such as AIDS, (AIDS) tuberculosis, and leprosy. Cachexia is apparently caused by the body's overproduction of TNF. In 1998 the FDA approved the use of thalidomide in the treatment of ENL, although distribution was to be closely regulated because of the drug's dangerous teratogenic properties. In AIDS patients, in addition to treating cachexia, thalidomide was also useful in treating lesions of the mouth and throat, and early tests indicated that the drug may inhibit the replication of the AIDS virus.More recent studies suggest that thalidomide may have activity against multiple myeloma, a variety of solid tumours, and other hematologic cancers. In addition to its ability to inhibit production of TNF, it appears that thalidomide may inhibit production of other immunoregulatory substances and may inhibit the growth of new blood vessels (angiogenesis), possibly by blocking growth factors that stimulate blood-vessel formation. The use of thalidomide has been shown to improve response rate in patients with multiple myeloma; however, no increase in overall survival has been observed.
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Thalidomide — Général Nom IUPAC 2 (2,6 Dioxopipéridin 3 yl)isoindol 1,3 dione No CA … Wikipédia en Français
thalidomide — [ talidɔmid ] n. f. • v. 1960; de (acide N ph)thal(y glutamique), ide et imide, de amide ♦ Méd. Tranquillisant qui s est révélé tératogène (v. 1961). ● thalidomide nom féminin Médicament utilisé pour ses propriétés anti inflammatoires et… … Encyclopédie Universelle
Thalidomide — 1958, from phthalimidoglutarimide, based on abbreviated form of naphthalene; a morning sickness drug responsible for severe birth defects in Europe from 1956 to 1961, when it was withdrawn. It was never approved for use in America thanks to the… … Etymology dictionary
thalidomide — ► NOUN ▪ a drug formerly used as a sedative, but found to cause malformation of the fetus when taken in early pregnancy … English terms dictionary
thalidomide — [thə lid′ə mīd΄] n. [< THALLIC + (IM)IDO + (glutari)mide < GLUT(EN) + (TART)AR(IC) + IMIDE] a crystalline solid, C13H10N2O4, formerly used as a sedative and hypnotic: found to be responsible for severe birth deformities when taken during… … English World dictionary
Thalidomide — This article is about the drug. For the musical about a person with thalidomide disability, see Thalidomide!! A Musical. Thalidomide Systematic (IUPAC) name (RS) 2 (2,6 dioxopiperidin 3 yl) 1H isoind … Wikipedia
Thalidomide — Талидомид (Thalidomide) Химическое соединение … Википедия
thalidomide — [[t]θəlɪ̱dəma͟ɪd[/t]] 1) N UNCOUNT Thalidomide is a drug which used to be given to pregnant women, before it was discovered that it resulted in babies being born with wrongly shaped arms and legs. 2) ADJ: ADJ n Thalidomide is used to describe… … English dictionary
thalidomide — n. a drug formerly used as a sedative but found in 1961 to cause foetal malformation when taken by a mother early in pregnancy. Phrases and idioms: thalidomide baby (or child) a baby or child born deformed from the effects of thalidomide.… … Useful english dictionary
thalidomide — A hypnotic drug which, if taken in early pregnancy, may cause the birth of infants with phocomelia and other defects; under investigational use for treatment of leprosy and as an immunomodulator in HIV infections and graft vs. host reactions. * * … Medical dictionary