/fee'neuh thuy"euh zeen', -zin/, n.
1. Chem. a grayish-green to greenish-yellow, crystalline, water-insoluble solid, C12H9NS, used chiefly as an insecticide and vermifuge, and in the synthesis of pharmaceuticals.
2. Pharm. any of a class of medications used principally to treat psychotic symptoms, as delusions or hallucinations, and excessive excitability.
[1890-95; PHENO- + THIAZINE]

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      widely used anthelmintic (worming agent) in veterinary medicine. Phenothiazine is an organic compound effective against a broad range of parasites in cattle, horses, poultry, sheep, and swine. A highly toxic drug, it is not recommended for human use and is not effective in dogs or cats.

      Some of the most useful antipsychotic drugs are derivatives of phenothiazine. They are widely used to treat the symptoms of persons suffering from schizophrenia, psychotic depression, the manic phase of manic-depression, and organic psychoses. The phenothiazines suppress or eliminate such symptoms as hallucinations, delusions, agitation, and disordered thinking. The drugs apparently achieve their tranquillizing effect by blocking the transmission of dopamine in the brain. Among the most widely used phenothiazines are chlorpromazine (marketed under Thorazine and other trade names), thioridazine (Mellaril), and trifluoperazine (Stelazine).

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Universalium. 2010.

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  • phenothiazine — [fē΄nō thī′ə zēn΄] n. [ PHENO + THIAZINE] a yellowish, crystalline substance, C12H9NS, used as an insecticide, in the treatment of worm infections in livestock, and in the synthesis of tranquilizers …   English World dictionary

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  • Phenothiazine — One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain. Examples of phenothiazines include: chlorpromazine (brand name:… …   Medical dictionary

  • phenothiazine — fentiazinas statusas T sritis chemija apibrėžtis Heterociklinis junginys. formulė C₆H₄:(NH)(S):C₆H₄ atitikmenys: angl. phenothiazine rus. фенотиазин …   Chemijos terminų aiškinamasis žodynas

  • phenothiazine — noun a) A polycyclic heterocycle consisting of two benzene rings fused to one of thiazine; thiodiphenylamine, dibenzothiazine b) Any of a family of pharmaceuticals, derived from this compound, used to treat schizophrenia etc …   Wiktionary

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