/uy'preuh nuy"euh zid/, n. Pharm.
a compound, C9H13N3O, used in the treatment of mental depression and tuberculosis.
[1950-55; I(SO)PRO(PYL) + NI(COTINE) + AZ- + -ID4]

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      the first drug of the monoamine-oxidase inhibitor series to be introduced into medicine (1958). It was employed as an antidepressant until it was found to cause liver damage. Prior to its introduction as an antidepressant, iproniazid was studied as a drug similar in function to the antituberculotic drug isoniazid, which it resembles in chemical structure. It prevents the enzymatic breakdown of norepinephrine, the brain-neurotransmitter substance concerned with emotional stimulation. It does so by inhibiting the enzyme monoamine oxidase.

      Iproniazid has been replaced in antidepressant therapy by other members of the monoamine-oxidase inhibitor series (e.g., isocarboxazid, phenelzine, and tranylcypromine) and the tricyclic antidepressant drugs (e.g., imipramine, amitriptyline, and nortriptyline), which have less severe side effects.

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Universalium. 2010.

Look at other dictionaries:

  • Iproniazid — Systematic (IUPAC) name N isopropylisonicotinohydrazide Clinical data AHFS/Drugs.com …   Wikipedia

  • Iproniazid — Strukturformel Allgemeines Freiname Iproniazid Andere Namen …   Deutsch Wikipedia

  • iproniazid — noun Etymology: blend of isoniazid and propyl Date: 1952 a derivative C9H13N3O of isoniazid that is used as a monoamine oxidase inhibitor and was formerly used in treating tuberculosis …   New Collegiate Dictionary

  • iproniazid — noun A hydrazine drug formerly used as an antidepressant …   Wiktionary

  • iproniazid — An antituberculous and antidepressant agent similar to isoniazid, but more toxic and rarely used; it inhibits monoamine oxidase. The first antidepressant agent. * * * ipro·ni·a·zid .ī prə nī ə zəd n a derivative C9H13N3O of isoniazid that is a… …   Medical dictionary

  • iproniazid — n. compound used to treat depression (Pharmacology) …   English contemporary dictionary

  • iproniazid — ipro·ni·a·zid …   English syllables

  • iproniazid — ˌīprəˈnīəzə̇d noun ( s) Etymology: blend of isoniazid and propyl : a derivative C9H13N3O of isoniazid that is a monoamine oxidase inhibitor used as an antidepressant and formerly in treating tuberculosis …   Useful english dictionary

  • Iproniazid and the Monoamine Oxidase Inhibitors —    (MAOIs)    (from 1957).    This is an early class of drugs noted to have a significant effect on depression. The prehistory: In 1937, Caecilia Pugh and Juda Hirsch Quastel (1899–1987) at the biochemical laboratory of Cardiff City Mental… …   Historical dictionary of Psychiatry

  • Hydrazine (antidepressant) — Iproniazid, the first hydrazine MAOI to be discovered, and the first antidepressant drug ever marketed. The hydrazine antidepressants are a group of non selective and irreversible monoamine oxidase inhibitors (MAOIs) that were discovered and… …   Wikipedia

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