iproniazid

/uy'preuh nuy"euh zid/, n. Pharm.
a compound, C9H13N3O, used in the treatment of mental depression and tuberculosis.
[1950-55; I(SO)PRO(PYL) + NI(COTINE) + AZ- + -ID4]

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drug
      the first drug of the monoamine-oxidase inhibitor series to be introduced into medicine (1958). It was employed as an antidepressant until it was found to cause liver damage. Prior to its introduction as an antidepressant, iproniazid was studied as a drug similar in function to the antituberculotic drug isoniazid, which it resembles in chemical structure. It prevents the enzymatic breakdown of norepinephrine, the brain-neurotransmitter substance concerned with emotional stimulation. It does so by inhibiting the enzyme monoamine oxidase.

      Iproniazid has been replaced in antidepressant therapy by other members of the monoamine-oxidase inhibitor series (e.g., isocarboxazid, phenelzine, and tranylcypromine) and the tricyclic antidepressant drugs (e.g., imipramine, amitriptyline, and nortriptyline), which have less severe side effects.

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Universalium. 2010.

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  • iproniazid — noun A hydrazine drug formerly used as an antidepressant …   Wiktionary

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  • iproniazid — n. compound used to treat depression (Pharmacology) …   English contemporary dictionary

  • iproniazid — ipro·ni·a·zid …   English syllables

  • iproniazid — ˌīprəˈnīəzə̇d noun ( s) Etymology: blend of isoniazid and propyl : a derivative C9H13N3O of isoniazid that is a monoamine oxidase inhibitor used as an antidepressant and formerly in treating tuberculosis …   Useful english dictionary

  • Iproniazid and the Monoamine Oxidase Inhibitors —    (MAOIs)    (from 1957).    This is an early class of drugs noted to have a significant effect on depression. The prehistory: In 1937, Caecilia Pugh and Juda Hirsch Quastel (1899–1987) at the biochemical laboratory of Cardiff City Mental… …   Historical dictionary of Psychiatry

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