diethylstilbestrol

/duy eth'euhl stil bes"trawl, -trol/, n. Pharm.
a nonsteroidal synthetic estrogen, C18H20O2, used in medicine chiefly in the treatment of menopausal symptoms and in animal feeds for chemical caponization: formerly used during pregnancy for the prevention of miscarriage but discontinued owing to its association with an increased risk of vaginal and cervical cancers in women having had fetal exposure. Abbr.: DES
Also, diethylstilboestrol.
[1935-40; DI-1 + ETHYL + STILBESTROL]

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      nonsteroidal synthethic estrogen used as a drug and formerly used to promote growth of livestock. Unlike natural estrogens, DES remains active following oral administration. It is also administered as vaginal suppositories and by injection. DES breaks down more slowly in the body than do the natural estrogens.

      DES is used therapeutically to replace estrogen during menopause, to relieve painful menstrual periods (dysmenorrhea), to stimulate the development of secondary sexual characteristics in women with nonfunctioning ovaries, and to palliate advanced breast cancer in women and prostate cancer in men.

      Beginning in the 1940s and continuing for more than 20 years, DES was frequently prescribed to pregnant women to prevent miscarriages. In 1971 investigators demonstrated statistically that daughters of women taking DES had abnormally high rates of an otherwise rare form of cervicovaginal cancer. The use of DES and other estrogens during pregnancy is now proscribed in many countries.

      Until the 1970s it was common practice to stimulate the fattening of beef cattle and chickens by mixing small amounts of DES into the feed or by implanting pellets of DES under the skin in the ears of the animals. Concern over trace amounts of the hormone in meat led to bans on the use of DES as a livestock growth stimulant beginning in the early 1970s.

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Universalium. 2010.

Look at other dictionaries:

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  • diethylstilbestrol — diethylstilbestrol. См. диэтилстилбестрол. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • diéthylstilbestrol — ● diéthylstilbestrol nom masculin Médicament œstrogène puissant, prescrit de 1946 à 1977 à des femmes enceintes pour prévenir les avortements spontanés et traiter les hémorragies pendant la grossesse …   Encyclopédie Universelle

  • diethylstilbestrol — [dī eth′əlstil bes′trôl΄, dī eth′əl stil bes′trōl΄] n. [diethyl (< DI 1 + ETHYL) + STILBESTROL] a synthetic estrogen, C18H20O2, used as a substitute for natural estrogens: a probable carcinogen now banned by the FDA as a food supplement for… …   English World dictionary

  • Diéthylstilbestrol — Pour les articles homonymes, voir DES. Diéthylstilbestrol Général …   Wikipédia en Français

  • Diethylstilbestrol — Strukturformel Allgemeines Freiname Diethylstilbestrol Ande …   Deutsch Wikipedia

  • Diethylstilbestrol — The earliest synthetic (man made) form of the hormone estrogen. Diethylstilbesterol (DES) was once widely prescribed to prevent miscarriages and premature births. Its usage was standard practice in the 1950s and 1960s. Millions of women received… …   Medical dictionary

  • diethylstilbestrol — noun Etymology: International Scientific Vocabulary Date: 1938 a colorless crystalline synthetic compound C18H20O2 used as a potent estrogen but contraindicated in pregnancy for its tendency to cause cancer or birth defects in offspring called… …   New Collegiate Dictionary

  • diethylstilbestrol — noun An orally active synthetic nonsteroidal oestrogen, first synthesized in 1938 and withdrawn in the 1970s on being identified as a teratogen. Syn: DES …   Wiktionary

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